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TRIM26 is highly expressed in PCa and is associated with poor prognosis in patients with PCa. ( a ) Expression profile of TRIM26 in various cancer tissues assayed based on the Human Protein Atlas. ( b ) Comparative expression of TRIM26 in PCa and lung cancer. ( c ) Representative immunohistochemical staining of TRIM26 in normal prostate tissues and PCa tissues. ( d ) Association between TRIM26 expression and overall survival in patients with PCa ( n = 246 for each group). ( e ) Representative immunohistochemical staining of TRIM26 in BPH, PIN, and PCa tissues. ( f ) Proportion of TRIM26 expression in BPH, PIN, and PCa tissues. BPH: benign prostate hyperplasia; PCa: prostate cancer; PIN: prostatic intraepithelial neoplasia; TRIM26: the tripartite motif-containing protein 26; TCGA: The Cancer Genome Atlas; HR: hazard ratio; PRAD: prostate adenocarcinoma.

Journal: Asian Journal of Andrology

Article Title: Inhibition of the PI3K/AKT signaling pathway blocks the oncogenic activity of TRIM26 in prostate cancer cells

doi: 10.4103/aja202526

Figure Lengend Snippet: TRIM26 is highly expressed in PCa and is associated with poor prognosis in patients with PCa. ( a ) Expression profile of TRIM26 in various cancer tissues assayed based on the Human Protein Atlas. ( b ) Comparative expression of TRIM26 in PCa and lung cancer. ( c ) Representative immunohistochemical staining of TRIM26 in normal prostate tissues and PCa tissues. ( d ) Association between TRIM26 expression and overall survival in patients with PCa ( n = 246 for each group). ( e ) Representative immunohistochemical staining of TRIM26 in BPH, PIN, and PCa tissues. ( f ) Proportion of TRIM26 expression in BPH, PIN, and PCa tissues. BPH: benign prostate hyperplasia; PCa: prostate cancer; PIN: prostatic intraepithelial neoplasia; TRIM26: the tripartite motif-containing protein 26; TCGA: The Cancer Genome Atlas; HR: hazard ratio; PRAD: prostate adenocarcinoma.

Article Snippet: To this end, we analyzed the spectrum of TRIM26 expression in more than 20 cancers based on the Cancer Genome Atlas (TCGA) data from The Human Protein Atlas database ( https://www.proteinatlas.org/ ), as of March 10, 2024.

Techniques: Expressing, Immunohistochemical staining, Staining